Address

Contact Information

Email: Harish.Vashisth@unh.edu

Harish Vashisth

Ph.D. Student

Ph.D., 2010
“Molecular Dynamics Studies of Insulin”
Publications:

H. Vashisth and C. F. Abrams, “All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element,” Proteins: Structure, Function, and Bioinformatics, vol. 81, iss. 6, p. 1017–1030, 2013. [Bibtex] [doi]
@article{Vashisth_2013,
doi = {10.1002/prot.24255},
url = {https://doi.org/10.1002%2Fprot.24255},
year = 2013,
month = {feb},
publisher = {Wiley},
volume = {81},
number = {6},
pages = {1017--1030},
author = {Harish Vashisth and Cameron F. Abrams},
title = {All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element},
journal = {{Proteins: Structure, Function, and Bioinformatics}}
}

H. Vashisth, L. Maragliano, and C. Abrams, “DFG-flip in the insulin receptor kinase is facilitated by a helical intermediate state of the activation loop,” Biophysical Journal, vol. 102, iss. 8, p. 1979–1987, 2012. [Bibtex] [doi]
@article{Vashisth_2012,
doi = {10.1016/j.bpj.2012.03.031},
url = {https://doi.org/10.1016%2Fj.bpj.2012.03.031},
year = 2012,
month = {apr},
publisher = {Elsevier {BV}},
volume = {102},
number = {8},
pages = {1979--1987},
author = {Harish Vashisth and Luca Maragliano and Cameron~F. Abrams},
title = {{DFG}-Flip in the Insulin Receptor Kinase Is Facilitated by a Helical Intermediate State of the Activation Loop},
journal = {{Biophysical Journal}}
}

H. Vashisth and C. F. Abrams, “All-atom structural models for complexes of insulin-like growth factors IGF1 and IGF2 with their cognate receptor,” Journal of Molecular Biology, vol. 400, iss. 3, p. 645–658, 2010. [Bibtex] [doi]
@article{Vashisth_2010,
doi = {10.1016/j.jmb.2010.05.025},
url = {https://doi.org/10.1016%2Fj.jmb.2010.05.025},
year = 2010,
month = {jul},
publisher = {Elsevier {BV}},
volume = {400},
number = {3},
pages = {645--658},
author = {Harish Vashisth and Cameron F. Abrams},
title = {All-Atom Structural Models for Complexes of Insulin-Like Growth Factors {IGF}1 and {IGF}2 with Their Cognate Receptor},
journal = {{Journal of Molecular Biology}}
}

H. Vashisth and C. F. Abrams, “Docking of insulin to a structurally equilibrated insulin receptor ectodomain,” Proteins: Structure, Function, and Bioinformatics, p. NA–NA, 2010. [Bibtex] [doi]
@article{Vashisth_2010b,
doi = {10.1002/prot.22670},
url = {https://doi.org/10.1002%2Fprot.22670},
year = 2010,
publisher = {Wiley},
pages = {NA--NA},
author = {Harish Vashisth and Cameron F. Abrams},
title = {Docking of insulin to a structurally equilibrated insulin receptor ectodomain},
journal = {{Proteins: Structure, Function, and Bioinformatics}}
}

H. Vashisth and C. F. Abrams, “Ligand escape pathways and (un)binding free energy calculations for the hexameric insulin-phenol complex,” Biophysical Journal, vol. 95, iss. 9, p. 4193–4204, 2008. [Bibtex] [doi]
@article{Vashisth_2008,
doi = {10.1529/biophysj.108.139675},
url = {https://doi.org/10.1529%2Fbiophysj.108.139675},
year = 2008,
month = {nov},
publisher = {Elsevier {BV}},
volume = {95},
number = {9},
pages = {4193--4204},
author = {Harish Vashisth and Cameron F. Abrams},
title = {Ligand Escape Pathways and (Un)Binding Free Energy Calculations for the Hexameric Insulin-Phenol Complex},
journal = {{Biophysical Journal}}
}

Professional Experience

  1. 2019-
    Associate Professor
    University of New Hampshire
  2. 2014-2019
    Assistant Professor
    University of New Hampshire
  3. 2010-2014
    Postdoctoral Researcher
    University of Michigan