Journal Publications

44. Han J., Sheng T., Zhang Y., Cheng H., Gao J., Yu J., Gu Z. Bioresponsive Immunotherapeutic Materials. Advanced Materials 2209778 (2023).

43. Wen P., Wu W., Wang F., Zheng H., Liao Z., Shia J., Zhu C., Zhao P., Cheng H.*, Li H.*, Gu Z. * Cell delivery devices for cancer immunotherapy. Journal of Controlled Release 353, 875-888 (2023)

42. Badr H.O., El-Melegy T., Carey M., Natu V., Hassig M.Q., Johnson C., Qian Q., Li C.Y., Kushnir K., Colin-Ulloa E., Titova L.V., Martin J.L., Grimm R.L., Pai R., Kalra V., Karmakar A., Ruffino A., Masiuk S., Liang K., Naguib M., Wilson O., Magenau A., Montazeri K., Zhu Y., Cheng H., Torita T., Koyanagi M., Yanagimachi A., Ouisse T., Barbier M., Wilhelm F., Rogalev A., Björk J., Persson P.O., Rosen J., Hu Y., Barsoum M.W. Bottom-up, scalable synthesis of anatase nanofilament-based two-dimensional titanium carbo-oxide flakes. Materials Today 54, 8-17 (2022).

41. Deng J., Wang J., Shi J., Li H., Lu M., Fan Z., Gu Z.*, Cheng H.* Tailoring the physicochemical properties of nanomaterials for immunomodulation. Advanced Drug Delivery Reviews 180, 114039 (2022).

40. Li P.Y., Bearoff F., Zhu P., Fan Z., Zhu Y., Fan, M., Cort L., Kambayashi T, Blankenhorn E.P. *, Cheng H.* PEGylation Enables Subcutaneously Administered Nanoparticles to Induce Antigen-Specific Immune Tolerance. Journal of Controlled Release 331, 164-175 (2021).

39. Fan Z., Zhu P., Zhu Y., Wu K., Li Y.C., Cheng H.* Engineering Long-Circulating Nanomaterial Delivery Systems. Current Opinion in Biotechnology 66, 131-139 (2020).

38. Zhang X., Kang Y., Wang J., Yan J, Chen Q, Cheng H.*, Huang P.*, Gu Z.* Engineered PD-L1-Expressing Platelets Reverse New-Onset Type 1 Diabetes. Advanced Materials 32, 1907692 (2020).

37. Khalili M.,1 Zhou H.,1 Thadi A., Daniels L., Fan Z., Morano W.F., Ang J., Goldstein E., Polyak B., Mapow B.C., Cheng H., Bowne W.B. Slippery Nanoparticles as a Diffusion Platform for Mucin Producing Gastrointestinal Tumors. Annals of Surgical Oncology 27, 76-84 (2020). (1 authors contribute equally)

36. Ruan H., Hu Q., Wen D., Chen Q., Chen G., Lu Y., Wang J., Cheng H., Lu W., Gu Z. A Dual‐Bioresponsive Drug-Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade. Advanced Materials 31, 1806957 (2019).

35. Wen D., Chen G., Chen Q., Li P.Y., Cheng H.*, Gu Z.* Engineering Protein Delivery Depots for Cancer Immunotherapy. Bioconjugate Chemistry 30, 515-524 (2019).

34. Fan Z.,1 Deng J.,1 Li P.Y., Chery D.R., Su Y.,Zhu P., Kambayashi T., Blankenhorn E.P., Han L., Cheng H.* A new class of biological materials: Cell membrane-derived hydrogel scaffolds. Biomaterials 197, 244-254 (2019) (1 authors contribute equally) [PDF]

33. Ruan H., Bu L., Hu Q., Cheng H., Lu W., Gu Z. Strategies of Combination Drug Delivery for Immune Checkpoint Blockades. Advanced Healthcare Materials 8, 1801099 (2019).

32. Zhou H., Fan Z., Li P.Y., Deng J., Arhontouslis D.C., Li. C.Y., Bowne W.B., Cheng H.* Dense and dynamic polyethylene glycol shells cloak nanoparticles from uptake by liver endothelial cells for long blood circulation. ACS Nano 12, 10130-10141 (2018). (Cover)

This work has been reported by Physics World.

31. Qi H.,1 Zhou H.,1 Tang Q., Lee J.Y., Fan Z., Kim S., Staub M.C., Zhou T., Mei S., Han L., Pochan D.J. Cheng H.*, Hu W., Li. C.Y.* Block copolymer crystalsomes with an ultrathin shell to extend blood circulation time. Nature Communications 9, 3005 (2018).(1 authors contribute equally).

30. Fan Z.,1 Li P.Y.,1 Deng J., Bady S.C., Cheng H.* Cell membrane coating for reducing nanoparticle-induced inflammatory responses to scaffold constructs. Nano Research 11, 5573-5583 (2018). [PDF]

29. Zhang X.,  Wang C.,  Wang J.,  Hu Q.,  Langworthy B., Ye Y., Sun W.,  Lin J.,  Wang T., Fine J., Cheng H.,  Dotti G., Huang P.,  Gu Z., PD‐1 Blockade cellular vesicles for cancer immunotherapy. Advanced Materials 30,170112 (2018).

28. Li Y.P.1, Fan Z.1Cheng H.* Cell membrane bioconjugation and membrane-derived nanomaterials for immunotherapy. Bioconjugate Chemistry 29, 624-634 (2018).

 27. Zhou H., Fan Z., Lemons P.K., Cheng H.A facile approach to functionalize cell membrane-coated nanoparticles. Theranostics 6, 1012-1022 (2016). Front Cover

26. Zhou H., Fan Z., Deng J., Lemons P.K., Arhontouslis D.C., Bowne W.B., Cheng H.*  Hyaluronidase embedded in nanocarrier PEG shell for enhanced tumor penetration and highly efficient antitumor efficacy. Nano Letters 16, 3268-3277 (2016).

This work was highlighted by Drexel University in President’s Report 2016 as an example of innovative researches at Drexel in 2016, and in ScienceDaliy and American Council on Science and Health.

25. Wang Q.1, Cheng H.1*, Peng H., Zhou H., Li P.Y., Langer R.* Non-genetic engineering of cells for drug delivery and cell-based therapy. Advanced Drug Delivery Reviews 91, 125-140 (2015). (1 authors contribute equally)

24. Fan Z., Zhou H., Li P.Y., Speer J.E., Cheng H.* Structural elucidation of cell membrane-derived nanoparticles using molecular probes. Journal of Materials Chemistry B 2, 8231-8238 (2014).

23. Gu Z.,  Dang T.T., Ma M.L., Tang B.C., Cheng H., Jiang S., Dong Y., Zhang Y., Anderson D.G. Glucose-responsive microgels integrated with enzyme nanocapsules for closed-loop insulin delivery. ACS Nano 7, 6758-6766, (2013).

22. Dang T.T., Thai A.V., Cohen J., Slosberg J.E., Siniakowicz K., Doloff J.C., Ma M.,  Hollister-Lock J., Tang K.M., Gu Z., Cheng H., Weir G.C.,  Langer R., Anderson D.G., Enhanced function of immuno-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug. Biomaterials 34, 5792-5801 (2013).

21. Gu Z., Aimetti A., Wang  Q., Dang T.T.,  Zhang Y., Veiseh O., Cheng H., Langer R., Anderson D.G. Injectable nano-network for glucose-mediated insulin delivery. ACS Nano 7, 4194-4201 (2013).

20. Kastrup C.J., Nahrendorf M., Figueiredo J.L., Lee H., Kambhampati S., Lee T., Cho S-W., Gorbatov R., Iwamoto Y., Dang T.T., Dutta P., Yeon J.H., Cheng H., Pritchard C.D., Vegas A.J., Siegel C.D., MacDougall S., Okonkwo M., Stone J.R., Coury A.J., Weissleder R., Langer R., Anderson D.G. Painting Blood Vessels and Atherosclerotic Plaques with an Adhesive Drug Depot. Proceedings of the National Academy of Sciences of the United States of America  109, 21444-21449 (2012).

19. Vacanti N., Cheng H., Hill P.S., Guerreior J., Dang T.T., Ma M., Watson S., Hwang N.S., Langer R., Anderson D.G. Localized delivery of dexamethasone from electrospun fibers reduces the foreign body response. Biomacromolecules 13, 3031-3038 (2012).

18. Cheng H., Byrska-Bishop M., Zhang C.T., Kastrup C.J., Hwang N.S., Tai A.K., Lee W.W., Xu X., Nahrendorf M., Langer R., Anderson D.G. Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell-selectin interaction kinetics. Biomaterials 33, 5004-5012 (2012).

17. Siegwart D.J., Whitehead K.A., Nuhn L., Sahay G., Cheng H., Jiang S., Ma M., Lytton-Jean A.K.R., Vegas A., Fenton P., Levins C.G., Love K.T., Lee H., Cortez C., Collins S.P., Li Y.F., Jang J., Querbes W., Zurenko C., Novobrantseva T., Langer R., Anderson D.G. Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery. Proceedings of the National Academy of Sciences of the United States of America 108,12996-13001 (2011).

16. Cheng H., Hill P.S., Siegwart D.J., Vacanti N., Lytton-Jean A.K.R., Cho S-W., Ye A., Langer R., Anderson D.G. A novel family of biodegradable poly(ester amide) elastomers. Advanced Materials 23, H95-100 (2011).            Feature by the materials science news site of Wiley-VCH at

15. Cheng H., Kastrup C.J., Ramanathan R., Siegwart D.J., Ma M., Bogatyrev S.R., Xu Q., Whitehead K.A., Langer R., Anderson D.G. Nanoparticulate cellular patches for cell-mediated tumoritropic delivery. ACS Nano 4, 625-631 (2010).    Featured in ACS Nano podcast:

14. Standley S.M., Toft D.J., Cheng H., Soukasene S., Chen J., Raja S.M., Band V., Band H., Cryns V.L., Stupp S.I. “Induction of cancer cell death by self-assembling nanostructures incorporating a cytotoxic peptide.”  Cancer Research 70, 3020-3026 (2010).

13. Raja S.M., Clubb R.C., Bhattacharyya M., Dimri M., Cheng H., Pan W., Ortega-Cava C., Naramura M., Lakku-Reddie A., Band V., Band H. A combination of trastuzumab and 17AAG induces enhanced ubiquitin ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cells.  Cancer Biology & Therapy 7, 1630-1640 (2008).

12. Cheng H., de la Cruz M.O. Hydrophobic-charged block copolymer micelles induced by oppositely charged surfaces: Salt and pH dependence. Macromolecules 39, 1961-1970 (2006).

11. Cheng H., Zhang K., Libera J. A., Bedzyk M.J., de la Cruz M.O. Polynucleotide adsorption to negatively charged surfaces in divalent salt solutions. Biophysical Journal 90, 1164-1174 (2006).

10. Libera J. A., Cheng H., de la Cruz M.O., Bedzyk M.J. Direct observation of cations and polynucleotides explains polyion adsorption to like-charged surfaces. Journal of Physical Chemistry B 109, 23001-23007 (2005).

9.  Cheng H., de la Cruz M.O. Rod-like polyelectrolytes adsorption onto charged surfaces in monovalent and divalent salt solutions. Journal of polymer Science Part B: Polymer Physics 42, 3642-3653 (2004).

8.  Cheng H., de la Cruz M.O. Adsorption of rod-like polyelectrolytes onto weakly charged surfaces. Journal of Chemical Physics 119, 12635-12644 (2003).

7.  Tuo X., Chen D., Cheng H., Wang X.G. Fabricating water-insoluble polyelectrolyte into multilayers with layer-by-layer self-assembly. Polymer Bulletin 54, 427-433 (2005).

6.  Deng Y., Tuo X., Cheng H., Wang X. Synthesis and h-aggregation of a novel polyelectrolyte bearing branched azo side chains. Chemical Journal of Chinese Universities 24, 1320-1324 (2003).

5. Cheng H., Tuo X., Gao W., Wang X. Synthesis and properties of a novel side-chain azo polyelectrolyte. Acta Polymerica Sinica 1, 96-101 (2002).

4.  Wang G., Cheng H., Wang X. Synthesis and properties of a photoresponsive azobenzene-containing hyperbranched polymer. Chemistry Letters 1, 78-79 (2002).

3.  Cheng H., Tuo X., Wang G., Wang X. A novel polyelectrolyte with branched azo side chains: synthesis, characterization and self-assembled nano-structures. Macromolecular Chemistry and Physics 202, 3530-3535 (2001).

2.  Wu L., Tuo X., Cheng H., Chen Z., Wang X. Synthesis, photoresponsive behavior, and self-assembly of poly(acrylic acid)-based azo polyelectrolytes. Macromolecules 34, 8005-8013 (2001).

1. Tuo X., Cheng H., Chen Z., Wang X. Studies on growth and architecture of self-assembled multilayers fabricated from side chain azo polyelectrolytes. Chemical Journal of Chinese Universities 22, 1581-1586 (2001).

Book Chapters

1. Deng, J., Li P.Y., Cheng, H. “Advances of Smart Materials for Wound Healing” Smart Materials for Tissue Engineering: Applications (Ed.: Q. Wang), Chapter 10, pp. 258-289, Royal Society of Chemistry, Cambridge, May 2017 DOI:10.1039/9781788010542-00258.